Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland.
Identifieur interne : 002328 ( Main/Exploration ); précédent : 002327; suivant : 002329Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland.
Auteurs : Sadanori Abe [États-Unis] ; Kunhua Fan ; Chi-Tang Ho ; Geetha Ghai ; Kan YangSource :
- Journal of medicinal food [ 1096-620X ] ; 2007.
English descriptors
- KwdEn :
- Animals, Anticarcinogenic Agents (administration & dosage), Apoptosis, Citrus sinensis (chemistry), Diet, Female, Flavones (administration & dosage), Flavones (analysis), Fruit (chemistry), Hyperplasia (prevention & control), Mammary Glands, Animal (pathology), Mice, Mice, Inbred C57BL, Mitosis, Phytotherapy, Plant Extracts (administration & dosage), Plant Extracts (chemistry).
- MESH :
- chemical , administration & dosage : Anticarcinogenic Agents, Flavones, Plant Extracts.
- chemical , analysis : Flavones.
- chemistry : Citrus sinensis, Fruit, Plant Extracts.
- pathology : Mammary Glands, Animal.
- prevention & control : Hyperplasia.
- Animals, Apoptosis, Diet, Female, Mice, Mice, Inbred C57BL, Mitosis, Phytotherapy.
Abstract
Cancer chemoprevention via the ingestion of natural substances is a current topic of considerable interest. Flavonoids are a family of biologically active phytochemicals having a variety of biological effects. Orange peel extract (OPE) is an abundant source of polymethoxyflavones (PMFs) with potential chemopreventive properties. The OPE used here was a mixture containing tangeretin (19.0%), heptamethoxyflavone (15.24%), tetramethoxyflavone (13.6%), nobiletin (12.49%), hexamethoxyflavone (11.06%), and sinensitin (9.16%). C57Bl/6 mice were fed a new "Western-style" diet (NWD), which had previously induced atypical hyperplasias in mammary gland, and NWD supplemented with a standardized OPE containing 30% PMFs. Mice were fed one of four diets: (1) AIN-76A diet (control); (2) NWD; 0.25% OPE in NWD; or (4) 0.5% OPE in NWD. After 3 months of feeding, atypical hyperplasias developed in mammary glands of mice fed NWD, but not in controls. After feeding OPE in NWD, atypical hyperplasias per mouse decreased in frequency compared to feeding NWD alone (P < .05 in mice fed 0.25% OPE). Apoptosis increased in OPE-treated groups (P < .01) with no inhibition of mitosis. Thus, a standardized preparation of OPE with 30% PMFs decreased development of an atypical hyperplastic lesion and increased apoptosis in ductal epithelial cells of mouse mammary gland.
DOI: 10.1089/jmf.2006.0215
PubMed: 17472462
Affiliations:
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II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland.</title><author><name sortKey="Abe, Sadanori" sort="Abe, Sadanori" uniqKey="Abe S" first="Sadanori" last="Abe">Sadanori Abe</name><affiliation wicri:level="1"><nlm:affiliation>Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021</wicri:regionArea><wicri:noRegion>New York 10021</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Kunhua" sort="Fan, Kunhua" uniqKey="Fan K" first="Kunhua" last="Fan">Kunhua Fan</name></author><author><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name></author><author><name sortKey="Ghai, Geetha" sort="Ghai, Geetha" uniqKey="Ghai G" first="Geetha" last="Ghai">Geetha Ghai</name></author><author><name sortKey="Yang, Kan" sort="Yang, Kan" uniqKey="Yang K" first="Kan" last="Yang">Kan Yang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17472462</idno><idno type="pmid">17472462</idno><idno type="doi">10.1089/jmf.2006.0215</idno><idno type="wicri:Area/PubMed/Corpus">000B46</idno><idno type="wicri:Area/PubMed/Curation">000B46</idno><idno type="wicri:Area/PubMed/Checkpoint">000B46</idno><idno type="wicri:Area/Ncbi/Merge">000698</idno><idno type="wicri:Area/Ncbi/Curation">000698</idno><idno type="wicri:Area/Ncbi/Checkpoint">000698</idno><idno type="wicri:doubleKey">1096-620X:2007:Abe S:chemopreventive:effects:of</idno><idno type="wicri:Area/Main/Merge">002407</idno><idno type="wicri:Area/Main/Curation">002328</idno><idno type="wicri:Area/Main/Exploration">002328</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland.</title><author><name sortKey="Abe, Sadanori" sort="Abe, Sadanori" uniqKey="Abe S" first="Sadanori" last="Abe">Sadanori Abe</name><affiliation wicri:level="1"><nlm:affiliation>Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Strang Cancer Prevention Center at The Rockefeller University, New York, New York 10021</wicri:regionArea><wicri:noRegion>New York 10021</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Kunhua" sort="Fan, Kunhua" uniqKey="Fan K" first="Kunhua" last="Fan">Kunhua Fan</name></author><author><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name></author><author><name sortKey="Ghai, Geetha" sort="Ghai, Geetha" uniqKey="Ghai G" first="Geetha" last="Ghai">Geetha Ghai</name></author><author><name sortKey="Yang, Kan" sort="Yang, Kan" uniqKey="Yang K" first="Kan" last="Yang">Kan Yang</name></author></analytic><series><title level="j">Journal of medicinal food</title><idno type="ISSN">1096-620X</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anticarcinogenic Agents (administration & dosage)</term><term>Apoptosis</term><term>Citrus sinensis (chemistry)</term><term>Diet</term><term>Female</term><term>Flavones (administration & dosage)</term><term>Flavones (analysis)</term><term>Fruit (chemistry)</term><term>Hyperplasia (prevention & control)</term><term>Mammary Glands, Animal (pathology)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mitosis</term><term>Phytotherapy</term><term>Plant Extracts (administration & dosage)</term><term>Plant Extracts (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anticarcinogenic Agents</term><term>Flavones</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Flavones</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term><term>Fruit</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Mammary Glands, Animal</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Hyperplasia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Diet</term><term>Female</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mitosis</term><term>Phytotherapy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cancer chemoprevention via the ingestion of natural substances is a current topic of considerable interest. Flavonoids are a family of biologically active phytochemicals having a variety of biological effects. Orange peel extract (OPE) is an abundant source of polymethoxyflavones (PMFs) with potential chemopreventive properties. The OPE used here was a mixture containing tangeretin (19.0%), heptamethoxyflavone (15.24%), tetramethoxyflavone (13.6%), nobiletin (12.49%), hexamethoxyflavone (11.06%), and sinensitin (9.16%). C57Bl/6 mice were fed a new "Western-style" diet (NWD), which had previously induced atypical hyperplasias in mammary gland, and NWD supplemented with a standardized OPE containing 30% PMFs. Mice were fed one of four diets: (1) AIN-76A diet (control); (2) NWD; 0.25% OPE in NWD; or (4) 0.5% OPE in NWD. After 3 months of feeding, atypical hyperplasias developed in mammary glands of mice fed NWD, but not in controls. After feeding OPE in NWD, atypical hyperplasias per mouse decreased in frequency compared to feeding NWD alone (P < .05 in mice fed 0.25% OPE). Apoptosis increased in OPE-treated groups (P < .01) with no inhibition of mitosis. Thus, a standardized preparation of OPE with 30% PMFs decreased development of an atypical hyperplastic lesion and increased apoptosis in ductal epithelial cells of mouse mammary gland.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Fan, Kunhua" sort="Fan, Kunhua" uniqKey="Fan K" first="Kunhua" last="Fan">Kunhua Fan</name><name sortKey="Ghai, Geetha" sort="Ghai, Geetha" uniqKey="Ghai G" first="Geetha" last="Ghai">Geetha Ghai</name><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name><name sortKey="Yang, Kan" sort="Yang, Kan" uniqKey="Yang K" first="Kan" last="Yang">Kan Yang</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Abe, Sadanori" sort="Abe, Sadanori" uniqKey="Abe S" first="Sadanori" last="Abe">Sadanori Abe</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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